Hydrazine hydrate (1:1) → HCID 86701893, compound

HRID 527290Notes

Reaction equation

HRID 527290 reaction equation
C([C:5]1[CH:6]=[C:7]([NH:11][C:12](SC)=[C:13]([C:17]#[N:18])[C:14]([NH2:16])=O)[CH:8]=[CH:9][CH:10]=1)(C)(C)C.[OH2:21].[NH2:22][NH2:23]>CCO>[NH2:18][C:17]1[NH:23][N:22]=[C:12]([NH:11][C:7]2[CH:6]=[CH:5][C:10]([C:13]([CH3:17])([CH3:14])[CH3:12])=[CH:9][CH:8]=2)[C:13]=1[C:14]([NH2:16])=[O:21]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86701894HCID 86701894, compound

Product 1

HCID 86701893HCID 86701893, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
75 °C

Procedure

3-((3-(tert-butyl)phenyl)amino)-2-cyano-3-(methylthio)acrylamide was then suspended in 10 mL EtOH and hydrazine hydrate (124 μL, 1.0 eq.) was added dropwise. Reaction was heated at 75° C. until intermediate was absent (HPLC). Once intermediate was absent (18 hrs), reaction was brought to room temperature and filtered to obtain 5-amino-3-((4-(tert-butyl)phenyl)amino)-1H-pyrazole-4-carboxamide as a yellow powder. Product was allowed to dry under vacuum for 1 hr.

Workup

  1. customReaction
  2. custom(18 hrs), reaction
  3. customwas brought to room temperature
  4. filtrationfiltered

Sources & evidence

ORD record
ord-4ea211900eaf49c29860ab23a1df10bb
Source dataset
uspto-grants-2016_05
Patent number
US09346792B2

Reaction notes

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