反应详情

温度

75 °C

Dissolved 0.500 g 2-cyano-3,3-bis(methylthio)acrylamide in 15 mL EtOH and added 3-Chloro-4-morpholinoaniline (1.0 eq.). Stirred reaction at 75° C. until starting amide was absent by HPLC. Once complete (18 hrs), reaction was brought to room temperature and filtered to obtain a light yellow powder as product. Product was allowed to dry under vacuum for 1 hr. Product was then suspended in 10 mL EtOH and hydrazine hydrate (1 eq.) was added dropwise. Reaction was heated at 75° C. until intermediate was absent (HPLC). Once intermediate was absent (18 hrs), reaction was brought to room temperature and filtered to obtain 5-amino-3-((3-chloro-4-morpholinophenyl)amino)-1H-pyrazole-4-carboxamide as a yellow powder. Product was allowed to dry under vacuum for 1 hr.

1. customreaction at 75° C.
2. customOnce complete (18 hrs), reaction
3. customwas brought to room temperature
4. filtrationfiltered
5. customto obtain a light yellow powder as product
6. customto dry under vacuum for 1 hr
7. customReaction
8. custom(18 hrs), reaction
9. customwas brought to room temperature
10. filtrationfiltered