反应详情

温度

60 °C

A solution of 2-(4-(N-cyano-S-methylsulfonimidoyl)benzyl)isoindoline-1,3-dione (preparation 6c, 684 mg, 2.02 mmol) and 1,2-diaminoethane (243 μL, 219 mg, 3.64 mmol) in a mixture of acetonitrile (8 mL), tetrahydrofuran (4 mL) and ethanol (4 mL) is heated at 60° C. for 5 h. All volatiles are removed under reduced pressure and the residue is suspended in dichloromethane. The mixture is filtered and the filtrate is concentrated under reduced pressure. Yield: 326 mg (77% of theory); ESI mass spectrum: [M+H]+=210; r.t. HPLC: 0.223 min (V001_007).

1. customAll volatiles are removed under reduced pressure
2. filtrationThe mixture is filtered
3. concentrationthe filtrate is concentrated under reduced pressure
4. customr.t
5. custom0.223 min (V001_007)