4-(Isopropylthio)benzylamine → 2-(4-(N-cyano-S-isopropylsulfinimidoyl)benzyl)isoindoline-1,3-dione

HRID 527348Notes

Reaction equation

HRID 527348 reaction equation
[C:1]([N:3]=[S:4]([C:7]1[CH:24]=[CH:23][C:10]([CH2:11][N:12]2[C:20](=[O:21])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]2=[O:22])=[CH:9][CH:8]=1)[CH2:5][CH3:6])#[N:2].[CH:25](SC1C=CC(CN)=CC=1)(C)C>>[C:1]([N:3]=[S:4]([C:7]1[CH:24]=[CH:23][C:10]([CH2:11][N:12]2[C:20](=[O:21])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]2=[O:22])=[CH:9][CH:8]=1)[CH:5]([CH3:25])[CH3:6])#[N:2]

Participants

3

Reactant 2

HCID 608843194-(Isopropylthio)benzylamineHCID 867116152-(4-(N-cyano-S-ethylsulfinimidoyl)benzyl)isoindoline-1,3-dione

Product 1

HCID 867116182-(4-(N-cyano-S-isopropylsulfinimidoyl)benzyl)isoindoline-1,3-dione

Procedure

The title compound is prepared in analogy to preparation 13a, substituting 4-(ethylthio)-benzylamine with 4-(isopropylthio)benzylamine ESI mass spectrum: [M+H]+=352; r.t. HPLC: 0.50 min (X012_S01).

Workup

  1. customr.t
  2. custom0.50 min (X012_S01)

Sources & evidence

ORD record
ord-1d800c98c8f14ddaa155bb2a15465f78
Source dataset
uspto-grants-2016_05
Patent number
US09346794B1

Reaction notes

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