2-(4-(Methylthio)benzyl)isoindoline-1,3-dione → 2-(5-Methylsulfanyl-pyridin-2-ylmethyl)-isoindole-1,3-dione

HRID 527354Notes

Reaction equation

HRID 527354 reaction equation
[CH3:1][S:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][N:8]2[C:16](=[O:17])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]2=[O:18])=C[CH:4]=1.CSC1C=CC(NC)=[N:27]C=1>>[CH3:1][S:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][N:8]2[C:16](=[O:17])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]2=[O:18])=[N:27][CH:4]=1

Participants

3

Reactant 2

HCID 79600652-(4-(Methylthio)benzyl)isoindoline-1,3-dioneHCID 68974266(5-Methylsulfanyl-pyridin-2-yl)-methylamine

Product 1

HCID 867116242-(5-Methylsulfanyl-pyridin-2-ylmethyl)-isoindole-1,3-dione

Procedure

The title compound is prepared in analogy to preparation 6a, substituting 4-(methylthio)-benzylamine with (5-methylsulfanyl-pyridin-2-yl)-methylamine (preparation 16a). ESI mass spectrum: [M+H]+=285; r.t. HPLC: 0.51 min (X012_S01).

Workup

  1. customr.t
  2. custom0.51 min (X012_S01)

Sources & evidence

ORD record
ord-7cc8766b50384fd7b23d32f05d907c26
Source dataset
uspto-grants-2016_05
Patent number
US09346794B1

Reaction notes

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