Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 527354Generated: November 2, 2026

2-(4-(Methylthio)benzyl)isoindoline-1,3-dione → 2-(5-Methylsulfanyl-pyridin-2-ylmethyl)-isoindole-1,3-dione

https://huagongshe.com/reaction/527354

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(4-(Methylthio)benzyl)isoindoline-1,3-dioneHCID 7960065—
Reactant(5-Methylsulfanyl-pyridin-2-yl)-methylamineHCID 68974266—
Product2-(5-Methylsulfanyl-pyridin-2-ylmethyl)-isoindole-1,3-dioneHCID 86711624—

Reaction Steps

The title compound is prepared in analogy to preparation 6a, substituting 4-(methylthio)-benzylamine with (5-methylsulfanyl-pyridin-2-yl)-methylamine (preparation 16a). ESI mass spectrum: [M+H]+=285; r.t. HPLC: 0.51 min (X012_S01).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09346794B1
Source datasetuspto-grants-2016_05
ORD IDord-7cc8766b50384fd7b23d32f05d907c26
Source noteuspto-grants-2016_05