2-(4-(N-cyano-S-methylsulfonimidoyl)benzyl)isoindoline-1,3-dione → 2-(5-(N-Cyano-S-methylsulfonimidoyl)pyridin-2-yl)-isoindole-1,3-dione

HRID 527355Notes

Reaction equation

HRID 527355 reaction equation
C(N=S(C1C=CC(CN2C(=O)C3C(=CC=CC=3)C2=O)=CC=1)(C)=[O:5])#N.[C:25]([N:27]=[S:28]([C:30]1[CH:31]=[CH:32][C:33]([N:36]2[C:44](=[O:45])[C:43]3[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=3)[C:37]2=[O:46])=[N:34][CH:35]=1)[CH3:29])#[N:26]>>[C:25]([N:27]=[S:28]([C:30]1[CH:31]=[CH:32][C:33]([N:36]2[C:44](=[O:45])[C:43]3[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=3)[C:37]2=[O:46])=[N:34][CH:35]=1)([CH3:29])=[O:5])#[N:26]

Participants

3

Reactant 2

HCID 867116102-(4-(N-cyano-S-methylsulfonimidoyl)benzyl)isoindoline-1,3-dioneHCID 86711626HCID 86711626, compound

Product 1

HCID 867116252-(5-(N-Cyano-S-methylsulfonimidoyl)pyridin-2-yl)-isoindole-1,3-dione

Procedure

The title compound is prepared in analogy to preparation 6c, substituting 2-(4-(N-cyano-S-methylsulfinimidoyl)benzyl)isoindoline-1,3-dione with 2-(5-(N-cyano-S-methylsulfinimidoyl)pyridin-2-yl)-isoindole-1,3-dione (preparation 16c). ESI mass spectrum: [M+H]+=341; r.t. HPLC: 0.88 min (Z018_S04).

Workup

  1. customr.t
  2. custom0.88 min (Z018_S04)

Sources & evidence

ORD record
ord-dc048a09b9174a9199efc02fb2bec3b0
Source dataset
uspto-grants-2016_05
Patent number
US09346794B1

Reaction notes

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