反应详情

温度

80 °C

Sodium methanethiolate (1.60 g, 22.8 mmol) is added to a solution of 4-fluoro-3-methyl-benzonitrile (2.50 g, 18.5 mmol) in DMF, and the mixture is heated at 80° C. for 15 min. All volatiles are evaporated, and the residue is treated with water. The mixture is extracted with ethyl acetate twice, and the organic layer is dried over Na2SO4 and concentrated. Yield: 3.0 g (99% of theory); ESI mass spectrum: [M+H]+=164; r.t. HPLC: 0.61 min (X011_S03).

1. customAll volatiles are evaporated
2. additionthe residue is treated with water
3. extractionThe mixture is extracted with ethyl acetate twice
4. dry with materialthe organic layer is dried over Na2SO4
5. concentrationconcentrated
6. customr.t
7. custom0.61 min (X011_S03)