反应详情

A mixture of 2-(4-(N,S-dimethylsulfonimidoyl)benzyl)isoindoline-1,3-dione (189 mg, 0.58 mmol) and 1,2-diaminoethane (132 μL, 3.44 mmol) in a 2:1:1 mixture of acetonitrile, tetrahydrofuran and ethanol (2 mL) is heated at reflux for 1 h. All volatiles are removed under reduced pressure, and the residue is treated with dichloromethane. The mixture is filtered, and the filtrate is concentrated under reduced pressure. Yield: 114 mg (85% of theory); ESI mass spectrum: [M+H]+=199; r.t. HPLC: 0.22 min (X011_S03).

1. temperatureis heated
2. temperatureat reflux for 1 h
3. customAll volatiles are removed under reduced pressure
4. additionthe residue is treated with dichloromethane
5. filtrationThe mixture is filtered
6. concentrationthe filtrate is concentrated under reduced pressure
7. customr.t
8. custom0.22 min (X011_S03)