反应详情

To 1-(2,6-dihydroxyphenyl)ethanone O-acetyloxime (Intermediate 9, 437 mg) pyridine (4.0 ml) was added and the reaction mixture was stirred at reflux for 2 hours. After the addition of HCl (4.0 ml of a 5M aqueous solution), the mixture was extracted 3 times with Et2O and the collected organic layers were washed with HCl (1M, aqueous solution). The organic phase was dried over sodium sulphate and filtered. Evaporation afforded the title compound (137 mg).

1. temperatureat reflux for 2 hours
2. extractionwas extracted 3 times with Et2O
3. washthe collected organic layers were washed with HCl (1M, aqueous solution)
4. dry with materialThe organic phase was dried over sodium sulphate
5. filtrationfiltered
6. customEvaporation