反应详情

To 1-(2,6-dihydroxy-4-methylphenyl)ethanone O-acetyloxime (Intermediate 18, 1.0 g) pyridine (10 ml) was added and the reaction mixture was stirred at reflux under N2 for 2 hours. After the addition of HCl (10.0 ml of a 5M aqueous solution), the mixture was extracted 3 times with Et2O and the gathered organic phases were washed with HCl (1M). The separated organic phase was then dried over sodium sulphate, filtered and evaporated to afford 345 mg of the title compound.

1. temperatureat reflux under N2 for 2 hours
2. extractionwas extracted 3 times with Et2O
3. washthe gathered organic phases were washed with HCl (1M)
4. dry with materialThe separated organic phase was then dried over sodium sulphate
5. filtrationfiltered
6. customevaporated