反应详情

3,6-dimethyl-1,2-benzisoxazol-4-ol (Intermediate 19, 345 mg) was dissolved in acetonitrile (10.0 ml) and then 1-fluoro-4-nitrobenzene (298 mg, 2.11 mmol) and potassium carbonate (877 mg, 6.34 mmol) were added. The reaction mixture was stirred and heated at reflux overnight. After removal of the volatiles, the residue was purified by silica gel chromatography eluting with a gradient cHex/EtOAc from 100/0 to 50/50 to afford the title compound (208 mg).

1. temperatureheated
2. temperatureat reflux overnight
3. customAfter removal of the volatiles
4. customthe residue was purified by silica gel chromatography
5. washeluting with a gradient cHex/EtOAc from 100/0 to 50/50