反应详情

1-(2,6-bis{[(methyloxy)methyl]oxy}phenyl)-2-methyl-1-propanone (Intermediate 36, 1.58 g, 5.89 mmol) was dissolved in methanol (40.0 ml) and an aqueous solution of HCl (23.6 mL of a 2M aqueous solution, 47.1 mmol) was added. The reaction mixture was refluxed for 1 hour. After quenching with water, the reaction mixture was extracted with ethyl acetate. The gathered organic layers were dried over sodium sulphate, filtered and evaporated to afford the title compound (916 mg).

1. temperatureThe reaction mixture was refluxed for 1 hour
2. customAfter quenching with water
3. extractionthe reaction mixture was extracted with ethyl acetate
4. dry with materialThe gathered organic layers were dried over sodium sulphate
5. filtrationfiltered
6. customevaporated