Stannous chloride dihydrate → HCID 67960637, compound

HRID 527536Notes

Reaction equation

HRID 527536 reaction equation
[CH3:1][CH:2]([C:4]1[C:8]2[C:9]([O:13][C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][N:15]=3)=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][N:5]=1)[CH3:3].O.O.[Sn](Cl)Cl>C(O)C>[CH3:3][CH:2]([C:4]1[C:8]2[C:9]([O:13][C:14]3[N:15]=[CH:16][C:17]([NH2:20])=[CH:18][CH:19]=3)=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][N:5]=1)[CH3:1]

Participants

4

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 67960030HCID 67960030, compound2×

Product 1

HCID 67960637HCID 67960637, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

3-(1-methylethyl)-4-[(5-nitro-2-pyridinyl)oxy]-1,2-benzisoxazole (Intermediate 41, 8.7 mg) was dissolved in 3.0 ml of ethanol. Tin(II) chloride dihydrate (19.7 mg, 0.087 mmol) was added and the reaction mixture was stirred at 80° C. for 3 hours. After quenching with water and extraction with ethyl acetate, the gathered organic layers were dried over sodium sulphate, filtered and evaporated to afford the title compound.

Workup

  1. customAfter quenching with water and extraction with ethyl acetate
  2. dry with materialthe gathered organic layers were dried over sodium sulphate
  3. filtrationfiltered
  4. customevaporated

Sources & evidence

ORD record
ord-5550fb642f7141eab41dc2b6dcc8a99f
Source dataset
uspto-grants-2016_05
Patent number
US09346790B2

Reaction notes

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