反应详情

温度

0 °C

Ethyl 2-[[tert-butyl(dimethyl)silyl]oxymethyl]-6-(methoxymethoxy)benzoate (Intermediate 177, 950 mg, 2.68 mmol) was dissolved in dichloromethane (30 ml), the solution was cooled to 0° C. and trifluoroacetic acid (2 ml) was added. After 3 h stirring at 0° C. water (20 ml) was added at 0° C. and two phases were separated. The organic layer was dried over Na2SO4 and evaporated in vacuo to afford a colourless oil that was purified by flash chromatography (Biotage system) on silica gel using cyclohexane to cyclohexane/ethyl acetate 7:3 as eluents affording the title compound (0.345 g) as a colorless oil.

1. additionwas added at 0° C.
2. customtwo phases were separated
3. dry with materialThe organic layer was dried over Na2SO4
4. customevaporated in vacuo
5. customto afford a colourless oil that
6. customwas purified by flash chromatography (Biotage system) on silica gel