Diiodomethane → HCID 67966806, compound

To a solution of 2,4,6-trichlorophenol (307 mg, 1.557 mmol) in 12.0 mL of DCM, at −40° C., 1M solution in hexane of diethylzinc (1.557 mL, 1.557 mmol) was added. After stirring at that temperature for 15 minutes, CH2I2 (0.126 mL, 1.557 mmol) was added. After stirring for additional 15 minutes, 4-methylidene-5-{[(methyloxy)methyl]oxy}-3,4-dihydro-2H-chromene (169 mg, 0.819 mmol) dissolved in 3.0 mL of DCM was added. The cold bath was removed and the mixture was stirred at room temperature for 2 hours. The mixture was diluted with DCM, washed with a 10% aqueous solution of HCl 2 times, then with an aqueous saturated solution of NaHCO3 2 times, an aqueous saturated solution of Na2SO3 2 times and brine (2 times). The organic layer was then dried over Na2OS4, filtered and evaporated and the residue was purified by flash chromatography (Biotage SP1) on silica gel using cyclohexane/ethyl acetate from 100:0 to 95:5. Collected residue was dissolved in DCM and washed (two times) with KOH (30% aq sol). The organic layer was dried over sodium sulphate, filtered and evaporated to afford the title compound (145 mg).

1. stirringAfter stirring for additional 15 minutes
2. additionwas added
3. customThe cold bath was removed
4. stirringthe mixture was stirred at room temperature for 2 hours
5. additionThe mixture was diluted with DCM
6. washwashed with a 10% aqueous solution of HCl 2 times
7. dry with materialThe organic layer was then dried over Na2OS4
8. filtrationfiltered
9. customevaporated
10. customthe residue was purified by flash chromatography (Biotage SP1) on silica gel
11. dissolutionCollected residue was dissolved in DCM
12. washwashed (two times) with KOH (30% aq sol)
13. dry with materialThe organic layer was dried over sodium sulphate
14. filtrationfiltered
15. customevaporated

ORD record

ord-96938752bf7749799cef9b8d51398207

Source dataset

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09346790B2