反应详情

6-(4-morpholinyl)-3-[3-(trifluoromethyl)phenyl]-1,5(6H)-pyridazindicarboxylic acid, diethyl ester (10.73 g, 0.024 mole) was refluxed in DMF (150 mL) for 30 min. The mixture was poured into water and extracted 3×100 mL with ethyl acetate. The organic layer was dried (MgSO4), filtered through silica gel, and evaporated in vacuo to give a crude solid which was recrystallized from cyclohexane/ethyl acetate to give 6-[3-(trifluoromethyl)phenyl]-4-pyridazinecarboxylic acid ethyl ester (3.34 g, 47% yield, Compound No. 1) as a brown solid.

1. extractionextracted 3×100 mL with ethyl acetate
2. dry with materialThe organic layer was dried (MgSO4)
3. filtrationfiltered through silica gel
4. customevaporated in vacuo
5. customto give a crude solid which
6. customwas recrystallized from cyclohexane/ethyl acetate