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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 527782Generated: November 1, 2026

1,4-Dibromobutane → 2-(Butyloxy)-8-(methyloxy)-9-[4-(1-piperidinyl)butyl]-9H-purin-6-amine formic acid salt

https://huagongshe.com/reaction/527782

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-DibromobutaneHCID 8056—
ReactantPiperidineHCID 8082—
ReactantHCID 178450357HCID 178450357—
Product2-(Butyloxy)-8-(methyloxy)-9-[4-(1-piperidinyl)butyl]-9H-purin-6-amine formic acid saltHCID 66727006—

Reaction Steps

Prepared similarly to Intermediate 20 from 2-(butyloxy)-8-(methyloxy)-1H-purin-6-amine trifluoroacetate, 1,4-dibromobutane and piperidine but with sequential mass directed autopreparations using Method A followed by Method D.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09346806B2
Source datasetuspto-grants-2016_05
ORD IDord-a160d3de9cea4b069e675656373bfff0
Source noteuspto-grants-2016_05