1,4-Dibromobutane → 2-(Butyloxy)-8-(methyloxy)-9-[4-(1-piperidinyl)butyl]-9H-purin-6-amine formic acid salt
Reaction equation
FC(F)(F)[C:3]([OH:5])=[O:4].[CH2:8]([O:12][C:13]1[NH:14][C:15]([NH2:24])=[C:16]2[C:20]([N:21]=1)=[N:19][C:18]([O:22][CH3:23])=[N:17]2)[CH2:9][CH2:10][CH3:11].Br[CH2:26][CH2:27][CH2:28][CH2:29]Br.[NH:31]1[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH:3]([OH:5])=[O:4].[CH2:8]([O:12][C:13]1[N:21]=[C:20]2[C:16]([N:17]=[C:18]([O:22][CH3:23])[N:19]2[CH2:26][CH2:27][CH2:28][CH2:29][N:31]2[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]2)=[C:15]([NH2:24])[N:14]=1)[CH2:9][CH2:10][CH3:11]Participants
4
Procedure
Prepared similarly to Intermediate 20 from 2-(butyloxy)-8-(methyloxy)-1H-purin-6-amine trifluoroacetate, 1,4-dibromobutane and piperidine but with sequential mass directed autopreparations using Method A followed by Method D.
Sources & evidence
- ORD record
- ord-a160d3de9cea4b069e675656373bfff0
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09346806B2
Reaction notes
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