Trifluoroacetic acid → HCID 178448279, compound

HRID 527824Notes

Reaction equation

HRID 527824 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][C@@H:9]([NH:13][C:14]1[N:22]=[C:21]2[C:17]([N:18]=[C:19]([O:29][CH3:30])[N:20]2C2CCCCO2)=[C:16]([NH2:31])[N:15]=1)[CH2:10][CH2:11][CH3:12]>CO>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][C@@H:9]([NH:13][C:14]1[NH:22][C:21]2[C:17]([N:18]=[C:19]([O:29][CH3:30])[N:20]=2)=[C:16]([NH2:31])[N:15]=1)[CH2:10][CH2:11][CH3:12]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59252563HCID 59252563, compound

Product 1

HCID 178448279HCID 178448279, compoundYield 103.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Trifluoroacetic acid (1 ml, 1.48 g, 7.08 mmol) was added to a stirred solution of N2-[(1R)-1-methylbutyl]-8-(methyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2,6-diamine (0.613 g, 1.833 mmol) in methanol (10 ml). The resultant mixture was stirred for 66 hours under an atmosphere of nitrogen and then evaporated to give the title compound as an off-white solid (0.690 g).

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-a5cbdc77f03440be9b6fa4da96e0ddb9
Source dataset
uspto-grants-2016_05
Patent number
US09346806B2

Reaction notes

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