Azepane → 6-Amino-9-[5-(hexahydro-1H-azepin-1-yl)pentyl]-2-{[(1S)-1-methylbutyl]oxy}-7,9-dihydro-8H-purin-8-one

HRID 527838Notes

Reaction equation

HRID 527838 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C@H:9]([O:13][C:14]1[NH:15][C:16]([NH2:25])=[C:17]2[C:21]([N:22]=1)=[N:20][C:19]([O:23]C)=[N:18]2)[CH2:10][CH2:11][CH3:12].Br[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]Cl.[NH:33]1[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1>>[NH2:25][C:16]1[N:15]=[C:14]([O:13][C@@H:9]([CH3:8])[CH2:10][CH2:11][CH3:12])[N:22]=[C:21]2[C:17]=1[NH:18][C:19](=[O:23])[N:20]2[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][N:33]1[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1

Participants

4

Reactant 3

HCID 8119AzepaneHCID 960701-Bromo-5-chloropentaneHCID 178448285HCID 178448285, compound

Product 1

HCID 448167376-Amino-9-[5-(hexahydro-1H-azepin-1-yl)pentyl]-2-{[(1S)-1-methylbutyl]oxy}-7,9-dihydro-8H-purin-8-one

Procedure

Prepared similarly to Example 19 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-1H-purin-6-amine trifluoroacetate, 1-bromo-5-chloropentane and hexahydro-1H-azepine.

Sources & evidence

ORD record
ord-d3cbda002fb54413a316719fa7d0d0b2
Source dataset
uspto-grants-2016_05
Patent number
US09346806B2

Reaction notes

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