関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 6-Iodo-2,3-dihydrobenzofuran | HCID 67115456 | — |
| 反応物 | HCID 178508691 | HCID 178508691 | — |
| 触媒 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 178508699 | HCID 178508699 | 44% |
反応手順
To a solution of S2-2 (50 mg, 0.2 mmol) in DMF (2 mL) was added 8-mercaptoadenine (34 mg, 0.2 mmol), Cs2CO3 (99.4 mg, 0.3 mmol) and PdCl2(dppf) (33 mg, 0.02 mmol). The mixture was degassed for 5 minutes with argon and stirred at 80° C. under argon protection for 48 h. The resulting mixture was concentrated under reduced pressure and the residue was purified by flash chromatography (CH2Cl2:MeOH, 100:0 to 90:10) to provide S2-3 (25 mg, 44% yield) as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09346808B2 |
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| 出典データセット | uspto-grants-2016_05 |
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| ORD ID | ord-85c9be7c331e4c8a8e438662a053567f |
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| 出典メモ | uspto-grants-2016_05 |
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