反应详情

温度

80 °C

To a solution of S2-2 (50 mg, 0.2 mmol) in DMF (2 mL) was added 8-mercaptoadenine (34 mg, 0.2 mmol), Cs2CO3 (99.4 mg, 0.3 mmol) and PdCl2(dppf) (33 mg, 0.02 mmol). The mixture was degassed for 5 minutes with argon and stirred at 80° C. under argon protection for 48 h. The resulting mixture was concentrated under reduced pressure and the residue was purified by flash chromatography (CH2Cl2:MeOH, 100:0 to 90:10) to provide S2-3 (25 mg, 44% yield) as a yellow solid.

1. customThe mixture was degassed for 5 minutes with argon
2. concentrationThe resulting mixture was concentrated under reduced pressure
3. customthe residue was purified by flash chromatography (CH2Cl2:MeOH, 100:0 to 90:10)
4. customto provide S2-3 (25 mg, 44% yield) as a yellow solid