Bromide ion → HCID 86713731, compound

Temperature

25 °C

To a solution of 2-bromoethaneamomium bromide (410 mg, 2 mmol) in 20 mL of CH2Cl2 was added triethylamine (3697 μL, 5 mmol). The resulting mixture was stirred at a temperature of about 25° C. for 30 min, then cooled down at 0° C. 2-methylpropane-2-sulfinic chloride (0.73 mL, 2.2 mmol) was added dropwise, kept stirring for 1 hr and allowed to warm up to a temperature of about 25° C. and stirred for about 16 hours. The resulting mixture was condensed and purified by flash chromatography to provide 2-methyl-propane-2-sulfinic acid (2-bromo-ethyl)-amide as a white solid (0.42 g, 86% yield).

1. temperaturecooled down at 0° C
2. stirringkept stirring for 1 hr
3. temperatureto warm up to a temperature of about 25° C.
4. stirringstirred for about 16 hours
5. customcondensed
6. custompurified by flash chromatography

ORD record

ord-d3a10e0401694fdaa0d0508f192de5f6

Source dataset

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09346808B2