反应详情

To 7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-carboxylic acid tert-butyl ester (intermediate 1) (0.5 g, mmol) dissolved in diethyl ether (20 ml) was added HCl in dioxane (ml, M) and the reaction mixture was stirred for 5 hours at room temperature. The precipitate was isolated by filtration, and washed with diethyl ether (2×5 ml). The precipitate was suspended in THF (50 ml) and stirred vigorously with K2CO3 (5 gram) for 3 hours. After filtration and evaporation of the solvent in vacuo, the product was obtained as an off-white compound.

1. customThe precipitate was isolated by filtration
2. washwashed with diethyl ether (2×5 ml)
3. stirringstirred vigorously with K2CO3 (5 gram) for 3 hours
4. filtrationAfter filtration and evaporation of the solvent in vacuo
5. customthe product was obtained as an off-white compound