7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro- → 4-(6,9-Diaza-spiro[4.5]dec-9-yl)-7H-pyrrolo[2,3-d]pyrimidine

HRID 527882Notes

Reaction equation

HRID 527882 reaction equation
C(OC([N:8]1[CH2:15][CH2:14][N:13]([C:16]2[C:17]3[CH:24]=[CH:23][NH:22][C:18]=3[N:19]=[CH:20][N:21]=2)[CH2:12][C:9]21[CH2:11][CH2:10]2)=O)(C)(C)C.Cl[C:26]1[C:27]2C=CNC=2N=CN=1.C(OC(N1CCNCC21CCCC2)=O)(C)(C)C>>[CH2:11]1[C:9]2([CH2:12][N:13]([C:16]3[C:17]4[CH:24]=[CH:23][NH:22][C:18]=4[N:19]=[CH:20][N:21]=3)[CH2:14][CH2:15][NH:8]2)[CH2:27][CH2:26][CH2:10]1

Participants

4

Reactant 3

HCID 53566827H-Pyrrolo(2,3-d)pyrimidine, 4-chloro-HCID 574772807-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-carboxylic acid tert-butyl esterHCID 68089093Tert-butyl 6,9-diazaspiro[4.5]decane-6-carboxylate

Product 1

HCID 668880294-(6,9-Diaza-spiro[4.5]dec-9-yl)-7H-pyrrolo[2,3-d]pyrimidine

Procedure

Prepared in a sequence similar to the sequence described for intermediates 1 and 2, starting from 4-chloro-7H-pyrrolo[2,3-d]pyrimidine and 6,9-diaza-spiro[4.5]decane-6-carboxylic acid tert-butyl ester.

Workup

  1. customPrepared in a sequence similar to the sequence

Sources & evidence

ORD record
ord-9f61423136804cf2b79f62de0657453f
Source dataset
uspto-grants-2016_05
Patent number
US09346809B2

Reaction notes

Loading…