Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 527882Generated: October 25, 2026

7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro- → 4-(6,9-Diaza-spiro[4.5]dec-9-yl)-7H-pyrrolo[2,3-d]pyrimidine

https://huagongshe.com/reaction/527882

Reaction equation

Participants

RoleNameHCIDCharge
Reactant7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro-HCID 5356682—
Reactant7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-carboxylic acid tert-butyl esterHCID 57477280—
ReactantTert-butyl 6,9-diazaspiro[4.5]decane-6-carboxylateHCID 68089093—
Product4-(6,9-Diaza-spiro[4.5]dec-9-yl)-7H-pyrrolo[2,3-d]pyrimidineHCID 66888029—

Reaction Steps

Prepared in a sequence similar to the sequence described for intermediates 1 and 2, starting from 4-chloro-7H-pyrrolo[2,3-d]pyrimidine and 6,9-diaza-spiro[4.5]decane-6-carboxylic acid tert-butyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09346809B2
Source datasetuspto-grants-2016_05
ORD IDord-9f61423136804cf2b79f62de0657453f
Source noteuspto-grants-2016_05