反应详情

2-Methoxy-4-methyl-benzenesulfonamide (201 mg, 1 mmol) was dissolved in H2O (10 mL). NaHCO3 (67 mg, 0.8 mmol) and KMnO4 (653 mg, 4.13 mmol) was added. The reaction mixture was stirred at reflux for 4 h. The reaction mixture was cooled to rt and filtered. the filtrate was acidified to pH=2 using conc. HCl. The precipitate was collected by filtration, washed with H2O affording the title compound as a white powder (117 mg).

1. temperatureat reflux for 4 h
2. filtrationfiltered
3. filtrationThe precipitate was collected by filtration
4. washwashed with H2O affording the title compound as a white powder (117 mg)