Hydrochloric Acid → HCID 86692135, compound

HRID 527898Notes

Reaction equation

HRID 527898 reaction equation
[N:1]1[C:6]2[NH:7][CH:8]=[CH:9][C:5]=2[C:4]([N:10]2[CH2:14][CH2:13][C@@H:12]([NH:15]C(=O)OC(C)(C)C)[CH2:11]2)=[N:3][CH:2]=1.[ClH:23]>>[ClH:23].[N:1]1[C:6]2[NH:7][CH:8]=[CH:9][C:5]=2[C:4]([N:10]2[CH2:14][CH2:13][C@@H:12]([NH2:15])[CH2:11]2)=[N:3][CH:2]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 68027129HCID 68027129, compound

Product 1

HCID 86692135HCID 86692135, compound

Procedure

(R)-tert-butyl 1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-ylcarbamate (600 mg, 1.97 mmol) was treated with HCl (in MeOH, 6 N, 5 mL) at the ambient temperature for 2 h. The volatiles were removed under reduced pressure to give (R)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine hydrochloride salt. MS (m/z): 204 (M+H)+.

Workup

  1. customThe volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-36ac951c99cc4c90bb4988350fc2902e
Source dataset
uspto-grants-2016_05
Patent number
US09346810B2

Reaction notes

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