HCID 68027538, compound → HCID 68027541, compound

HRID 527903Notes

Reaction equation

HRID 527903 reaction equation
[CH3:1][N:2]([C:25]1[CH:30]=[CH:29][C:28]([N+:31]([O-])=O)=[CH:27][N:26]=1)[C@@H:3]1[CH2:7][CH2:6][N:5]([C:8]2[C:9]3[CH:16]=[CH:15][N:14]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:24])([CH3:23])[CH3:22])[C:10]=3[N:11]=[CH:12][N:13]=2)[CH2:4]1>CO.[Ni]>[CH3:1][N:2]([C@@H:3]1[CH2:7][CH2:6][N:5]([C:8]2[C:9]3[CH:16]=[CH:15][N:14]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:22])([CH3:24])[CH3:23])[C:10]=3[N:11]=[CH:12][N:13]=2)[CH2:4]1)[C:25]1[CH:30]=[CH:29][C:28]([NH2:31])=[CH:27][N:26]=1

Participants

4

Reactant 1

HCID 68027538HCID 68027538, compound

Product 1

HCID 68027541HCID 68027541, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

To a solution of (R)-methyl-(5-nitro-pyridin-2-yl)-{1-[7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-pyrrolidin-3-yl}-amine (10 mmol) in methanol (100 mL) was added Raney Ni. The mixture was stirred at room temperature for 18 hours under 1 atm of H2. After filtration, it was concentrated to give the title compound.

Workup

  1. filtrationAfter filtration, it
  2. concentrationwas concentrated

Sources & evidence

ORD record
ord-21604ce5c289404896fd5be45bb60424
Source dataset
uspto-grants-2016_05
Patent number
US09346810B2

Reaction notes

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