HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 68027538, compound → HCID 68027541, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 68027538 | HCID 68027538 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 68027541 | HCID 68027541 | — |
Reaction Steps
To a solution of (R)-methyl-(5-nitro-pyridin-2-yl)-{1-[7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-pyrrolidin-3-yl}-amine (10 mmol) in methanol (100 mL) was added Raney Ni. The mixture was stirred at room temperature for 18 hours under 1 atm of H2. After filtration, it was concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09346810B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-21604ce5c289404896fd5be45bb60424 |
| Source note | uspto-grants-2016_05 |