6-Bromopyridine-3-carbonitrile → (R)-tert-butyl 3-((5-cyanopyridin-2-yl)(cyclopropyl)amino)pyrrolidine-1-carboxylate

HRID 527905Notes

Reaction equation

HRID 527905 reaction equation
[CH:1]1([NH:4][C@@H:5]2[CH2:9][CH2:8][N:7]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6]2)[CH2:3][CH2:2]1.Br[C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][N:19]=1>>[C:22]([C:21]1[CH:24]=[CH:25][C:18]([N:4]([CH:1]2[CH2:2][CH2:3]2)[C@@H:5]2[CH2:9][CH2:8][N:7]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6]2)=[N:19][CH:20]=1)#[N:23]

Participants

3

Reactant 2

HCID 50057186-Bromopyridine-3-carbonitrileHCID 53346626(R)-tert-Butyl 3-(cyclopropylamino)pyrrolidine-1-carboxylate

Product 1

HCID 66766463(R)-tert-butyl 3-((5-cyanopyridin-2-yl)(cyclopropyl)amino)pyrrolidine-1-carboxylate

Procedure

The title compound was prepared according to the procedures of Intermediate 2 (A) using (R)-tert-butyl 3-(cyclopropylamino)pyrrolidine-1-carboxylate and 6-bromonicotinonitrile under similar conditions MS (m/z): 329 (M+H)+.

Sources & evidence

ORD record
ord-2ac062a8d31b4cc883a59433c782e1fa
Source dataset
uspto-grants-2016_05
Patent number
US09346810B2

Reaction notes

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