反应详情

To a solution of indoline-5-carbonitrile (110 mg, 0.75 mmol) in 2.5 mL of MeOH was added tert-butyl 3-oxopyrrolidine-1-carboxylate (166 mg, 0.90 mmol) and HOAc (0.11 mL, 1.88 mmol) subsequently. After stirring at room temperature for 10 minutes, NaCNBH3 (57 mg, 0.90 mmol) was added and the mixture was then stirred at ambient temperature for 2 days. The volatiles were removed under vacuum. The residue was diluted with EtOAc, then washed with 1 N NaOH solution and brine, dried over Na2SO4, and evaporated in vacuo to afford the crude title compound for the next step use without further purification.

1. stirringthe mixture was then stirred at ambient temperature for 2 days
2. customThe volatiles were removed under vacuum
3. additionThe residue was diluted with EtOAc
4. washwashed with 1 N NaOH solution and brine
5. dry with materialdried over Na2SO4
6. customevaporated in vacuo