反应详情

A suspension of 6-bromo-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one (2.0 g; prepared according to WO 01/30782) in DMF (40 mL) was treated with 4-methoxybenzyl chloride (1.18 mL) and Cs2CO3 (8.5 g) and stirred at rt for 2 h. The solvent was evaporated under reduced pressure and the residue was partitioned between EA and water. The org. layer was washed with brine, dried over MgSO4 and evaporated under reduced pressure. The residue was triturated with Hept, affording a beige solid (2.8 g; 92% yield).

1. customThe solvent was evaporated under reduced pressure
2. customthe residue was partitioned between EA and water
3. washlayer was washed with brine
4. dry with materialdried over MgSO4
5. customevaporated under reduced pressure
6. customThe residue was triturated with Hept
7. customaffording a beige solid (2.8 g; 92% yield)