HRID527978

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3662392

3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANAL

C9H20O2Si

结构：O=C1CSc2ccc(N3C[C@H](CCNCC4Cn5c(=O)ccc6ccc(F)c4c65)OC3=O)cc2N1

HCID67348543

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)[Si](C)(C)OCCCN(CC[C@H]1CN(c2ccc3c(c2)NC(=O)CS3)C(=O)O1)CC1Cn2c(=O)ccc3ccc(F)c1c32

HCID67134432

未命名化合物

收率 87%

PROCEDURE

实验过程

Starting from the compound of Example 4 and 3-(tert-butyldimethylsilyloxy)-propionaldehyde and using procedure E, the title compound was obtained as a yellow foam (82 mg; 87% yield).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b5c13323cddb46b1984cbfbe290d9f76
来源数据集: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09346804B2
来源说明: uspto-grants-2016_05

反应 SMILES

[F:1][C:2]1[C:11]2[CH:12]([CH2:14][NH:15][CH2:16][CH2:17][C@@H:18]3[O:22][C:21](=[O:23])[N:20]([C:24]4[CH:25]=[CH:26][C:27]5[S:32][CH2:31][C:30](=[O:33])[NH:29][C:28]=5[CH:34]=4)[CH2:19]3)[CH2:13][N:9]3[C:10]=2[C:5]([CH:6]=[CH:7][C:8]3=[O:35])=[CH:4][CH:3]=1.[Si:36]([O:43][CH2:44][CH2:45][CH:46]=O)([C:39]([CH3:42])([CH3:41])[CH3:40])([CH3:38])[CH3:37]>>[C:39]([Si:36]([CH3:38])([CH3:37])[O:43][CH2:44][CH2:45][CH2:46][N:15]([CH2:14][CH:12]1[C:11]2=[C:10]3[C:5](=[CH:4][CH:3]=[C:2]2[F:1])[CH:6]=[CH:7][C:8](=[O:35])[N:9]3[CH2:13]1)[CH2:16][CH2:17][C@@H:18]1[O:22][C:21](=[O:23])[N:20]([C:24]2[CH:25]=[CH:26][C:27]3[S:32][CH2:31][C:30](=[O:33])[NH:29][C:28]=3[CH:34]=2)[CH2:19]1)([CH3:42])([CH3:41])[CH3:40]