HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-((Tert-butyldimethylsilyl)oxy)propanal → (RS)-1-[([3-(tert-butyl-dimethyl-silanyloxy)-propy]-{2-[(S)-2-oxo-3-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-yl)-oxazolidin-5-yl]-ethyl}-amino)-methyl]-9-fluoro-1,2-dihydro-pyrrolo[3,2,1-ij]quinolin-4-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-((Tert-butyldimethylsilyl)oxy)propanal | HCID 3662392 | — |
| Edukt | (1RS)-9-fluoro-1-({2-[(S)-2-oxo-3-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-yl)-oxazolidin-5-yl]-ethylamino}-methyl)-1,2-dihydro-pyrrolo[3,2,1-ij]quinolin-4-one | HCID 67348543 | — |
| Produkt | (RS)-1-[([3-(tert-butyl-dimethyl-silanyloxy)-propy]-{2-[(S)-2-oxo-3-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-yl)-oxazolidin-5-yl]-ethyl}-amino)-methyl]-9-fluoro-1,2-dihydro-pyrrolo[3,2,1-ij]quinolin-4-one | HCID 67134432 | 87% |
Reaktionsschritte
Starting from the compound of Example 4 and 3-(tert-butyldimethylsilyloxy)-propionaldehyde and using procedure E, the title compound was obtained as a yellow foam (82 mg; 87% yield).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09346804B2 |
| Quelldatensatz | uspto-grants-2016_05 |
| ORD ID | ord-b5c13323cddb46b1984cbfbe290d9f76 |
| Quellennotiz | uspto-grants-2016_05 |