反应详情

温度

140 °C

A mixture of 7-cyclopropyl-2,4-dichloro-6,7-dihydro-[1,4]dioxino[2,3-d]pyrimidine (93 mg, 0.40 mmol), morpholine (150 μL, 1.71 mmol) and triethylamine (80 μL, 0.57 mmol) in IMS (3 mL) was heated at 140° C. for 35 minutes using microwave irradiation before being concentrated in vacuo. The resulting residue was purified by column chromatography (SiO2, 0-20% ethyl acetate in cyclohexane) affording 2-Chloro-7-cyclopropyl-4-morpholin-4-yl-6,7-dihydro-[1,4]dioxino[2,3-d]pyrimidine as a white solid (98 mg, 87%). LCMS: RT=3.02 min, [M+H]+=284/286.

1. custommicrowave irradiation
2. concentrationbefore being concentrated in vacuo
3. customThe resulting residue was purified by column chromatography (SiO2, 0-20% ethyl acetate in cyclohexane)