反应详情

4-(2-Chloro-4-(trifluoromethyl)phenyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide (EXAMPLE 5) was prepared in the same manner as INTERMEDIATE D, step 3, starting from 4-(2-chloro-4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonyl chloride and using thiazol-2-amine instead of intermediate A. 1H NMR (400 MHz, DMSO-d6) δ ppm 3.73 (br. s., 2 H) 4.36 (t, J=4.45 Hz, 2 H) 6.32 (d, J=8.41 Hz, 1 H) 6.79 (d, J=4.50 Hz, 1 H) 7.14 (dd, J=8.61, 2.15 Hz, 1 H) 7.17-7.26 (m, 2 H) 7.73 (d, J=8.31 Hz, 1 H) 7.81-7.88 (m, 1 H) 8.06 (s, 1 H) 12.58 (br. s., 1 H).