Chloral Hydrate → Acetamide, 2-(hydroxyimino)-N-phenyl-
反応式
N1C2C(=CC=CC=2)C(C(O)=O)=CC=1.[NH:14]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:17](=O)[C:15]1=[O:16].NC1C=CC=CC=1.ClC(Cl)(Cl)C(O)O.Cl.[NH2:40][OH:41]>>[CH:21]1[CH:20]=[CH:19][C:24]([NH:14][C:15](/[CH:17]=[N:40]/[OH:41])=[O:16])=[CH:23][CH:22]=1参加物
実験手順
The quinoline-4-carboxylic acid [E] can be prepared using the classical Sandmeyer isatin synthesis followed by the Pfitzinger reacton. The aniline was reacted with chloral hydrate and hydroxylamine hydrochloride to afford the substituted isonitrosoacetanilide which was cyclized using a suitable acid catalyst to afford the isatin as described in. Alternatively the isatin can be bought from commercial sources. The isatin can then be converted into the corresponding substituted quinoline-4-carboxylic acid using the Pfitzinger reaction as in reference 17. In some instances the Pfitzinger reaction yielded a quinoline-2,4-dicarboxylic acid which was decarboxylated to the quinoline-4-carboxylic acid by reacting it in water for 2 h using a pressured tube at 200° C.
出典と根拠
- ORDレコード
- ord-b472b2add2f040e2bc9bb3e4ecd0d4ac
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09346814B2
反応ノート
読み込み中…