反应详情

N-Boc-glycine (7.31 g, 41.7 mmol) was dissolved in 100 mL of DCM and to the cooled (15° C.) solution N-hydroxysuccinimide (5.28 g, 45.9 mmol) was added. N,N′-dicyclohexylcarbodiimide (9.47 g, 45.9 mmol) was added to the formed suspension under vigorous stirring. After a few seconds, a cloudy white suspension formed, the mixture was allowed to reach room temperature and stirred for 1 h. It was subsequently filtrated over celite, washed with 50 mL saturated sodium bicarbonate, dried over sodium sulfate and concentrated in vacuo to yield a crystalline powder. Yield: 7.02 g, 61.8%

1. additionwas added
2. waitAfter a few seconds
3. customa cloudy white suspension formed
4. customto reach room temperature
5. filtrationIt was subsequently filtrated over celite
6. washwashed with 50 mL saturated sodium bicarbonate
7. dry with materialdried over sodium sulfate
8. concentrationconcentrated in vacuo
9. customto yield a crystalline powder