Trifluoroacetic acid → HCID 89705107, compound

HRID 528678Notes

Reaction equation

HRID 528678 reaction equation
[C:1]([C@@H:3]1[CH2:7][C:6]([F:9])([F:8])[CH2:5][N:4]1[C:10](=[O:20])[CH2:11][NH:12]C(=O)OC(C)(C)C)#[N:2].[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>C(#N)C>[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[NH2:12][CH2:11][C:10]([N:4]1[CH2:5][C:6]([F:8])([F:9])[CH2:7][C@H:3]1[C:1]#[N:2])=[O:20]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 89705558HCID 89705558, compound

Product 1

HCID 89705107HCID 89705107, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a cooled (0° C.) solution of (S)-tert-butyl 2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethylcarbamate (7.3 g, 25.2 mmol), obtained from step 7, in 150 mL of ACN was added trifluoroacetic acid (38.9 mL, 0.505 mol) dropwise. The mixture was stirred overnight and the volatiles were evaporated. The residue was washed with ether.

Workup

  1. customthe volatiles were evaporated
  2. washThe residue was washed with ether

Sources & evidence

ORD record
ord-6a2b68c20d7f4ce6bd1e936ac20a1058
Source dataset
uspto-grants-2016_05
Patent number
US09346814B2

Reaction notes

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