Hydrochloric Acid → HCID 18475684, compound

HRID 528680Notes

Reaction equation

HRID 528680 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=O)[C:5]2=[O:12].[OH-:13].[Na+].O=[C:16]([CH3:20])[C:17]([O-:19])=[O:18].Cl>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]=[C:6]([C:5]([OH:12])=[O:13])[CH:20]=[C:16]2[C:17]([OH:19])=[O:18]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 107735PyruvateHCID 2365665-Fluoroisatin

Product 1

HCID 18475684HCID 18475684, compound

Conditions

Temperature
110 °C

Procedure

To 5-fluoroindoline-2,3-dione (0.454 g, 2.75 mmol) was a 3M NaOH (5.46 mL, 16.52 mmol) solution added. The reaction mixture was heated until refluxing, and 2-oxopropanoate (0.364 g, 3.30 mmol) was added. After refluxing at 110° C. for 4 h, the mixture was cooled to room temperature. The pH was adjusted to 3-4 with 1M HCl, and the precipitate was filtered and washed with water to yield whitish crystals

Workup

  1. additionadded
  2. temperatureThe reaction mixture was heated
  3. temperatureuntil refluxing
  4. temperaturethe mixture was cooled to room temperature
  5. filtrationthe precipitate was filtered
  6. washwashed with water
  7. customto yield whitish crystals

Sources & evidence

ORD record
ord-805944825ea34f37ac179b83760f0023
Source dataset
uspto-grants-2016_05
Patent number
US09346814B2

Reaction notes

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