反应详情

A solution of 4-isobutylbenzoic acid (1.0 g, 5.6 mmol) in acetic acid (56 ml) was purged with argon. After addition of platinum(IV) oxide (0.38 g, 1.7 mmol) the reaction flask was filled with hydrogen gas. The reaction mixture was stirred under an atmosphere of hydrogen gas for 72 h at RT. The flask was purged with argon, and the catalyst was removed by filtration over Decalite. The filtrate was concentrated to dryness to give the title compound as a (7:3) cis/trans mixture. MS m/e: 183 ([M−H]−)

1. customThe flask was purged with argon
2. customthe catalyst was removed by filtration over Decalite
3. concentrationThe filtrate was concentrated to dryness