1-tert-Butyl 4-ethyl 5-oxoazepane-1,4-dicarboxylate → HCID 178451648, compound

HRID 528708Notes

Reaction equation

HRID 528708 reaction equation
C(O[C:4]([CH:6]1[C:12](=O)[CH2:11][CH2:10][N:9]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:8][CH2:7]1)=[O:5])C.[NH2:21][C:22]1[CH:26]=[CH:25][NH:24][N:23]=1>C(O)(=O)C>[C:17]([O:16][C:14]([N:9]1[CH2:8][CH2:7][C:6]2=[C:4]([OH:5])[N:23]3[C:22]([N:21]=[C:12]2[CH2:11][CH2:10]1)=[CH:26][CH:25]=[N:24]3)=[O:15])([CH3:18])([CH3:19])[CH3:20]

Participants

4

Reactant 2

HCID 44365701-tert-Butyl 4-ethyl 5-oxoazepane-1,4-dicarboxylateHCID 178418806HCID 178418806, compound

Product 1

HCID 178451648HCID 178451648, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

To 13.3 g (46.61 mmol) 5-oxo-azepane-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester in 8 mL acetic acid was added 3.87 g (46.61 mmol) 3-aminopyrazole and the reaction mixture was heated at 80° C. for 15 minutes. The resulting solid was collected by filtration and washed with TBME (3×10 mL) to give the desired product.

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with TBME (3×10 mL)

Sources & evidence

ORD record
ord-e1cccfaad91444ef972e850c0a54ccb7
Source dataset
uspto-grants-2016_05
Patent number
US09346816B2

Reaction notes

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