Hydrochloric Acid → Hydrochloric Acid

HRID 528711Notes

Reaction equation

HRID 528711 reaction equation
C(OC([N:8]1[CH2:28][CH2:27][C:12]2=[C:13]([N:20]3[CH2:26][CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[N:14]3[C:18]([N:19]=[C:11]2[CH2:10][CH2:9]1)=[CH:17][CH:16]=[N:15]3)=O)(C)(C)C.[ClH:29]>C(Cl)Cl.O1CCOCC1>[O:23]1[CH2:24][CH2:25][CH2:26][N:20]([C:13]2[N:14]3[C:18]([N:19]=[C:11]4[CH2:10][CH2:9][NH:8][CH2:28][CH2:27][C:12]=24)=[CH:17][CH:16]=[N:15]3)[CH2:21][CH2:22]1.[ClH:29]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 6797938810-[1,4]Oxazepan-4-yl-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester

Product 2

HCID 313Hydrochloric AcidHCID 6745769810-[1,4]Oxazepan-4-yl-6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To 88 mg (0.23 mmol) 10-[1,4]oxazepan-4-yl-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester in 3 mL DCM, was added 1.13 mL (4.5 mmol) HCl in dioxane (4 M), and the reaction was stirred at room temperature for 16 hours. The solvent was evaporated to give the desired product as a HCl salt.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-239ee4685529420a835d4895f16f8cae
Source dataset
uspto-grants-2016_05
Patent number
US09346816B2

Reaction notes

Loading…