Azetidine → 10-Azetidin-1-yl-3-iodo-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester

HRID 528718Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:23][CH2:22][C:12]2=[C:13](Cl)[N:14]3[C:18]([N:19]=[C:11]2[CH2:10][CH2:9]1)=[C:17]([I:20])[CH:16]=[N:15]3)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH:24]1[CH2:27][CH2:26][CH2:25]1>>[C:1]([O:5][C:6]([N:8]1[CH2:23][CH2:22][C:12]2=[C:13]([N:24]3[CH2:27][CH2:26][CH2:25]3)[N:14]3[C:18]([N:19]=[C:11]2[CH2:10][CH2:9]1)=[C:17]([I:20])[CH:16]=[N:15]3)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 10422Azetidine

HCID 8666717010-Chloro-3-iodo-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester

Product 1

HCID 6797946210-Azetidin-1-yl-3-iodo-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester

Procedure

The product was prepared using 10-chloro-3-iodo-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester and azetidine as the amine in route 1 (step e).

Workup

customThe product was prepared

Sources & evidence

ORD record: ord-03d98210bcdd48a38143533652eba734
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09346816B2

Reaction notes

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