反应详情

To 87 mg (0.2 mmol) 10-azetidin-1-yl-3-pyridin-2-ylethynyl-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester in 3 mL ethanol was added 11 mg (20% weight) palladium hydroxide, the reaction was purged 3 times with nitrogen then 3 times with hydrogen and was stirred at room temperature under a balloon of hydrogen for 16 hours. The mixture was purged twice with nitrogen, then the solution was filtered through a pad of celite. After evaporation of the solvent the product was purified by column chromatography (silica, heptane/EtOAc 9:1 to 3:7).

1. customthe reaction was purged 3 times with nitrogen
2. customThe mixture was purged twice with nitrogen
3. filtrationthe solution was filtered through a pad of celite
4. customAfter evaporation of the solvent the product
5. customwas purified by column chromatography (silica, heptane/EtOAc 9:1 to 3:7)