Hydrochloric Acid → Hydrochloric Acid

HRID 528729Notes

Reaction equation

HRID 528729 reaction equation
C(OC([N:8]1[CH2:28][CH2:27][C:12]2=[C:13]([N:20]3[CH2:23][CH2:22][C@H:21]3[CH2:24][O:25][CH3:26])[N:14]3[C:18]([N:19]=[C:11]2[CH2:10][CH2:9]1)=[CH:17][CH:16]=[N:15]3)=O)(C)(C)C.[ClH:29]>C(Cl)Cl.O1CCOCC1>[CH3:26][O:25][CH2:24][C@@H:21]1[CH2:22][CH2:23][N:20]1[C:13]1[N:14]2[C:18]([N:19]=[C:11]3[CH2:10][CH2:9][NH:8][CH2:28][CH2:27][C:12]=13)=[CH:17][CH:16]=[N:15]2.[ClH:29]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 67979328(S)-10-(2-methoxymethyl-azetidin-1-yl)-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester

Product 2

HCID 313Hydrochloric AcidHCID 67457896(S)-10-(2-Methoxymethyl-azetidin-1-yl)-6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To 60.1 mg (0.155 mmol) (S)-10-(2-methoxymethyl-azetidin-1-yl)-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester in 3 mL DCM was added 2 mL (3.1 mmol) HCl in dioxane (4 M) and the reaction was stirred at room temperature for 5 hours. The solvent was evaporated to give the desired product as a HCl salt.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-873616e7c7d44981b774e371295523cb
Source dataset
uspto-grants-2016_05
Patent number
US09346816B2

Reaction notes

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