Hydrochloric Acid → Hydrochloric Acid

HRID 528734Notes

Reaction equation

HRID 528734 reaction equation
C(OC([N:8]1[CH2:11][CH:10]([C:12]2[O:13][C:14]([CH3:17])=[CH:15][N:16]=2)[CH2:9]1)=O)(C)(C)C.[ClH:18]>O1CCOCC1>[ClH:18].[NH:8]1[CH2:11][CH:10]([C:12]2[O:13][C:14]([CH3:17])=[CH:15][N:16]=2)[CH2:9]1.[ClH:18]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 679793952-(1-Boc-3-azetidinyl)-5-methyloxazole

Product 2

HCID 313Hydrochloric AcidHCID 674577502-(Azetidin-3-yl)-5-methyloxazole hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 57 mg (0.24 mmol) 3-(5-methyl-oxazol-2-yl)-azetidine-1-carboxylic acid tert-butyl ester was added 2 mL (8 mmol) HCl in dioxane (4 M), and the reaction was stirred at room temperature for 1 hour. The solvent was evaporated to give the desired product as a HCl salt, which was used for the next step without further purification.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-0f29d1d5d926482f8b6efb58f7f58d2c
Source dataset
uspto-grants-2016_05
Patent number
US09346816B2

Reaction notes

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