反应详情

温度

90 °C

To 145 mg (0.67 mmol) 3-thiocarbamoyl-azetidine-1-carboxylic acid tert-butyl ester in 3 mL MeOH in a sealed tube was added 64 μL (0.8 mmol) chloroacetone, and the reaction was stirred at 90° C. for 3 hours. After evaporation of the solvent the product was purified by column chromatography (silica, heptane/EtOAc 8:2 to 6:4).

1. customAfter evaporation of the solvent the product
2. customwas purified by column chromatography (silica, heptane/EtOAc 8:2 to 6:4)